Amphibians and reptiles also exhibit high levels of species endemism. Notable among the 25 species of strictly endemic amphibians are species within the reed frogs (Hyperolius – five endemic species), forest treefrogs (Leptopelis - two endemic species), tree toads (Nectophrynoides – five endemic species), species in the Microhylidae family (four endemic species), and the Caeciliaidae family (five endemic species). New species continue to be discovered in this ecoregion.

Hyperolius africans is small to medium in size, the male reaching 43mm in length. The side of its snout is curved and the head width is 32-38% of its body length. The toes end in toe pads that enable the frog to climb up stems of grass and reeds. They have an enormous variety of brightly colored markings, with a profusion of stripes, spots, or stippling. Currently, populations are grouped by shared color patterns into subspecies. Some may be pale brown with darker spots or striped with lighter and darker brown. Others may be striped with thick bands of black and white with a yellow stripe running down the center. While, still others have red-brown spots on a light background.

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